Keto diet scientific review

Telephonefaxe-mail moc. All rights reserved This article has been cited by other articles in PMC. The physical body weight, body mass index, total cholesterol, low density lipoprotein LDL cholesterol, high density lipoprotein HDL cholesterol, triglycerides, fasting blood sugar, creatinine and urea levels were determined before and after the administration of the ketogenic diet.

Changes in these parameters were monitored after eight, 16 and 24 weeks of treatment. From week 1 to week HDL cholesterol levels considerably increased The level of total cholesterol decreased, whereas LDL cholesterol levels decreased after treatment. The level of triglycerides decreased following 24 weeks of treatment significantly.

The level of blood glucose decreased. The noticeable changes in the level of urea and creatinine were not statistically significant. It considerably reduced the body weight and body mass index of the patients. Furthermore, it decreased the level of triglycerides, LDL cholesterol and blood glucose, and increased the known level of HDL cholesterol. Administering a ketogenic diet for a relatively longer time period did not produce any significant side effects in the patients.

Therefore, the present study confirms that it is safe to use a ketogenic diet for a longer time period than previously demonstrated. Keywords: Diet, Ketosis, Obesity Obesity has become a serious chronic disease in both developed and developing countries. Furthermore, it is associated with a variety of chronic diseases 1 – 4. Each year from obesity-related diseases 56 It is estimated that in the United States alone approximatelypeople die. Different methods for reducing weight using reduced calorie and fat intake combined with exercise have failed to show sustained long-term effects 7 – 9.

Recent studies from various laboratories 1011including our own 12have proven that a high fat diet rich in polyunsaturated fatty acids ketogenic diet is fairly effective in reducing body weight and the risk factors for various chronic diseases. The ketogenic diet was introduced in In this diet originally, the fat to carbohydrate ratio is While there was a significant decrease in the weight of obese patients who were on a ketogenic diet 12the reverse occurred when the diet changed to one high in carbohydrates It should be noted that the concept that fat can be eaten ad libitum and still induce weight loss in obese subjects is not a recent one 13 – Incomplete oxidation of fatty acids by the liver results in the accumulation of ketone bodies in the body.

A ketogenic diet maintains the physical body in a state of ketosis, which is characterized by an elevation of D-b-hydroxybutyrate and acetoacetate. Mild ketosis is a natural phenomenon that occurs in humans during fasting and lactation 19 Postexercise ketosis is a well-known phenomenon in mammals.

Although the majority of the changes in the physiological parameters induced following exercise revert back to their normal values rapidly, the level of circulating ketone bodies increases for a few hours after muscular activity ceases It has been found that in trained individuals, a low blood ketone level protects against the development of hypoglycemia during prolonged intermittent exercise In addition, ketosis has a significant influence on suppressing hunger.

It is generally believed that high fat diets may result in the development of obesity and several other diseases such as coronary artery disease, cancer and diabetes. This view, however, is based on studies carried out in animals that were given a high fat diet rich in polyunsaturated fatty acids. In contrast, our laboratory has recently proven that a ketogenic diet modified the risk factors for heart disease in obese patients Although various short-term studies examining the effect of a ketogenic diet in reducing the weight of obese patients have been carried out 10its long-term effects in obese subjects are not known Therefore, the purpose of the present study was to investigate the long-term effects of a ketogenic diet on obesity and obesity-associated risk factors in a huge population of obese patients.

The body mass index BMI of women and men was The mean age was The mean age, initial height, bMI and weight for all patients are given in Table 1. Fasting blood tests were carried out for all of the subjects. Initially, all patients were subjected to liver and renal function tests, and glucose and lipid profiles, using fasting blood samples, and a complete blood count.

Thereafter, fasting blood samples were tested for total cholesterol, high density lipoprotein HDL cholesterol, low density lipoprotein LDL cholesterol, triglycerides, blood sugar, urea and creatinine levels at the eighth, week 16th and 24th. In addition, height and weight measurements, and blood pressure were monitored at each visit.

106 thoughts to “Keto diet scientific review”

  1. This Lancet article is based on bad science. Self-reported data over 25 years? Really? Also 40 grams of carbs is not Low Carb or Keto. I would hope that you as a medical professional (to be) should strive to be more informed! Meta analysis based on biased science is useless and spreading under a keto hash tag is deceptive.

    1. Ann Timmons Excellent comment. She had a bag of skittles, YouTube channel and a camera, so……..

  2. Well I guess us Diabetics are dead and have no hope. Thanks Doc. You may want to check out Dr Jason Fung. You might learn something from a seasoned Dr. who reversed more type 2 diabetes than all the hairs on your head. Also check out Dr Berg

  3. So according to this meta study: meat eaters dont eat vegetables?

  4. 40% carbs is as bad as 70% carbs…. you dont get any benefits unless its 5-10% carbs. In fact fast food is normally 40% carb, 40% fat, 20% protein…..just saying.

  5. My educated decision..hmmm?…(drum roll)…KETO/IF all the way!!!!.. and no I am definitely not sharing this video…sorry!

  6. plus diet keto u using for 5-6 weeks and back to normal food, no one is on keto diet whole life

  7. Nothing from this study can be extrapolated to be used as an indicator of plant based keto is better for vitality than normal animal fat keto.

    Not a useful video, especially titling it related to keto.

  8. There is a loss of objectivity between industries, if I may point out. The medical industry has tried unsuccessfully to control the supplement industry. I have an absurd medical study that says that the link between cancer risk and fruits and vegetables is weak- sorry to say there is competition between these groups. The doctors prefer to believe that the great variation in eating habits people have has no effect on health- just walk in the door, and theyve got your back.

  9. Carbs are mentioned in the study but specifically what carbs were used is not. There is a huge difference in the health and nutritional effects of table sugar and steel cut oats.

  10. I have been on the Atkins diet since 1996. One thing I quickly figured out is that very few people ever ate anything comparable to my diet. So I concluded that studies really do not apply to me. A low carb diet of 40% really is not low carb. So how is this study relevant to me?

  11. So the animal proteins being compared to the plant proteins, is that taking into consideration of the previously mentioned carbohydrates? Animal proteins are all over fast food. It is fast food that is unhealthy.

  12. Apparently Vitamin C and D have had a bad rap in the last 8 decades.. Drs Klenner, Pauling, levy and many more need a second look. The a
    Australian farmer Allen Smith (6o minutes, Proof of Life) deserves a long, hard look. Whole body means a whole look. Thanks

  13. This is a stupid misinformed video. Dear doctor what ever your name is…shut up

  14. Why are you using this data to argue against a keto diet? None of the diets were even low-carb, never mind keto. That seems pretty disingenuous.

  15. OK, Id like to know a little bit more about these test groups: how many of them smoked in their lives, how much sugar do they consume, do they take alcohol, do they all exercise equally, what do their family health histories look like, what are the stress levels theyve been subjected to in their lives? Etc, etc, etc. While diet may contribute to longevity, there are many other factors playing into it. You cannot attribute length of life solely to the amount of carbs people do or do not eat.

  16. Im sorry doctor, myself and many friends have used keto and intermittent fasting to achieve life changing results. Weve lost serious amounts of fat whilst boosting our health which is a win win

  17. A second year med student who read one Keto Diet research article and is now an expert on the Keto Diet. She on her way to being one of the millions of doctors that believes being a medical doctor means she qualified as a nutritionist. Ironically, medical doctors have around 6 hours of nutrition class and become self proclaimed experts.

    With that said, medical doctors also believe they are experts in pharmacology,, with around 6 hour of classes. Medical doctors also are self proclaimed experts in physical therapy, exercise physiology, etc.

    They definitely have the God Complex.

    The Violin MD (in reality a second year med student) is well on her way to becoming another omniscient, self proclaimed Goddess of medicine, nutrition, pharmacology, physical therapy, nutrition, etc.

    That we need, another maniacal physical, with more carp coming out of her mouth than her ass.

  18. Definitely not qualified to be talking about this, really need a dietician. Unfortunately medical Drs think they are knowledgeable in things way outside their scope of practice. I think you need to remove this video due to it being junk science/misleading

  19. youre so filled up with yourself to see the truth, 40% carbs is not low carb

  20. That 4 year difference isnt high school or university. It is actually the time youll be sh*tting yourself pushed around and treated mean by an underpaid caretaker in a nursing home. You wanna prolong that term? Be my guest. Eat carbs

  21. Keto diet found to suppress viral infection and this lady is too stupid

  22. I am not attacking anyone but did the low carb people ever enter the ketosis state? Because we dont know the ratio of the low carb diet group how carb they are consuming in percentage, so how do you know its keto diet?

  23. The cause of many sickness in the world is due to diet and only diet could reverse that. Does keto kill? I know those medication will kill you eventually …

  24. This is too simplified if you have insulin resistance the only way to reverse it is to drastically lower carbs thus lowering insulin

  25. so what I do is I just stay away from pretty well all junk food I ate a lot of plant proteins and a very small amount of I stay away from bread and do things in moderation

  26. agree Keto is a cheat diet and only a temporary fix, however this article never mentioned about eating fruit and what fruit does for your health. I am all fruit now and at 61 I have incredible health….NOW….before I ate similar to a keto diet and ended up with stage 3 kidney failure, Rheumatoid Arthritis, Spondylitis, pre diabetes, big knarly knuckles and could not even open a door, overweight and no energy. I was only 40 then. Fruit cured all of that. Before you all jump down on the sugar in fruit, remember this, the sugar in fruit is fructose and does not require insulin to move into the cells for your energy. It is the ONLY sugar that does this on its own. So you can eat fruit 24/7 and never will have have too much sugar floating around in your bloodstream, turning into acids, causing health issues. Doctors are not being told this and most are too indoctrinated to do their own research. The other thing that fruit does and no other food can, is move the lymphatic system, which is your garbage /toxin disposal system, ie it remvoes the toxins from your cells and excretes them out through your lymph nodes. If that gets clogged up and slows down or stops moving altogether then you have serious problems. Why….because if the lymph system is already full and not moving then your cells sit there with the toxins and that causes cellular degradation and cellular mutosis, ie your cancers and auto immune conditions, like I once had. If you are on a sad diet then DO NOT go all fruit to begin with as this will move your lymph system really fast and the detox can be quite harsh on the body and make you very sick. This is akin to alcoholics where they must detox them slowly, as too fast can kill them. I have found the younger people cope much better than older ones and can only put this down to the older you are the more build up of toxins you have sitting around. Be well and take your health back.

  27. What a bunch of BS in that the question even surfaces as to whether it kills. Shivone (spelling?) Please stop

  28. Well in most Asian country keto diet is really hard to follow because most of the main food are carbs rich like rice and noodles. But guess what? Obesity is not very common in asia unlike western countries, which also makes asian people has a longer live expectancy. The study just proves that you dont need diet full of fat to stay lean, healthier, and live longer. so I absolutely agree with her point about the study.

  29. I literally want to go back to school and finish my nursing degree. I want to learn more..its so Interesting. And I did a low carb diet, the grapefruit every 12 days , you eat carbs . I lost a lot of weight but got sick of all.tje meat..and I only liked, or could make a few green.vegatables.

  30. jumped way too fast to cutting keto and adding plant based protein without addressing insulin resistance resulting in my determination that this is vegan based rationale praise the god of vegans. BS

  31. However there is 50 other doctors with videos that are opposite this video.

  32. it gives me good results … but it makes me want to kill someone sometimes

  33. I think a good diet is nothing but …when u got hunger and then eat its a basic ,long term,good diet philosophy

  34. just look at the diet of the people living in the so called blue zones. none of the centenarians is on keto. But almost all of them eat lots of legumes and are rather high carb diets.
    Keto is maybe ok for short term weight loss but its nothing one can do for decades.

  35. Plant based? What plants? Those with high glyphosate and GMO? 70% of plants right now, are laboratory genetically made 😕 Those plants, are eating by animal and by us, thats why plant based vegans haves cancer and other diseases. I dont say keto or carnivore diet or GAPS diet that cure Autism and fatty liver and other diseases, are good!! To do keto or carnivore or GAPS for a year or 2 to boost your immunity, to cure type 2 diabetes and to lower insulin and sugar in the blood, is ok. To do intermitent fasting and fasting 24-36 hours for stem cells is also a big Ok. But after 2 years, after your health is come back, indeed we can eat full plant based protein or fatt but in 2 years the GENETICS will evolve so much and in the end (my opinion), we humans, we not evolve genetically So Fast like those seeds in the laboratory. In conclusion, those plants (grains, leafy greens, etc), are super mega genetically modified and you and I eat a super mega plant 😎 What your organism will say about that? Thats why, I repet, the cancer is huge on vegans to. Who haves the money to eat only organic plant? Non-Gmo? Many of us here in East-Europe, are working for 350-450$ on month. To pay bills? To live our lives? That why we eat garbage gmo plants, thats why we are full of toxins and from animal products to. Who haves money to eat only organic grass-feed? Lets be serious,,,, Thats why many jump on keto, because we eat, we do 24-36 hours fasts, we regenerate our organism and we need less 💸 for food. Here in Romania a 1kg of potato is 2$, man for real? For some gmo garbage potato? Lets be serious lady,,, Look in Lithuania were people work for 200$ on month, sad but true!! In Canada a worker haves 2000$ is a huge difference, yes you can eat grass-feed or organic plants!! Here we eat garbage plants and garbage animal products with all the toxins that we can put in them. Thats the reality and thats why Keto is all over the world right now!! I want to eat only plants (no animal products) but from were the 💸? I wish to vegans all the best in the world but they suffer to from those modified plants and full of toxins in growth process. I know is a negative comment but this is the truth!! Peace ✌️🙏

  36. here is the latest study
    A ketogenic diet extends longevity and healthspan in adult mice

  37. Interesting research but saying nothing about Keto. To stay in ketosis, you have to consume much less than 40% calories from carbs. Drawing any conclusions regarding Keto diet from the research on people consuming 40 and more % of calories from carbs is a methodological mistake.

  38. Im trying out the Carnivore diet. Im on day four. As for the life expectancy, Okinawans have some of the highest in the world and they attribute it largely to their consumption of sweet potatoes and fish. Even Okinawans in rural areas were living long lives.

  39. Well if you take into consideration that a lot of tryptophan is in grains or grain like foods ->tryptophan is the amino acid that creates serotonin then wouldnt eating a low tryptophan containing diet make you more depressed and/or anxious? Ie other than chicken and bananas how does a keto dieter get enough tryptophan in thier diet? My sibling that tried this diet for over a year developed worse anxiety. My opinion as a future Dietitian is that All or nothing diets are not good in the long run. Moderating is the key but definitely avoid stuff that is toxic and harmful like trans fat.

  40. Four years? So much experience! That is a young persons attitude. I am 68 something is going to take me out. I will happen Doctor, trust me. I have stepped back from diabetes, lost 35 pounds and lowered my blood pressure. God, four more years of life experience will kill me child. You have a lot of life to grow into. I have watched some of your videos, I had that kind of attitude at that age. Changing you behavior is nothing, easy, you will do it many times. And at my age so will I. Keep calm, have a sandwich, and get some years under you. Please dont respond to this, I dont care and have spent to much time on you already. Sensationalist journalism.

  41. It doesn’t make sense… this is not scientific… tell us how many died of diabetes related disease? How many died in cancer? How many died in heart problems?
    How could they track other foods each group was taking, like hydrogenate oils?
    Did those who were keto were high protein diet? Was it dirty keto ie lot of deli’s?

  42. I’m down 56 pounds since starting keto. Inflammation gone. Acid reflux gone. I have more mental focus. I even sleep better. I’m officially off my BP meds. Soon I’ll eventually come off the crap. Life changing for real. At least for me.

  43. im 65and i turned diabetic about 4 years ago and presently eating 2 meals a day /morning and evening .its about 2 /3 years with no pork /feeling better / im planning to quit meat completely i have a stew once in a while /chicken fish etc i take no meds now i was on insulin for a bout a year /ii dont take metraformin any more ….i dont sleep well so i thinking dieting well improve all my health need s what do you think i want to cure the diabeties

  44. You need to take a class in nutrition because he did not teach you that as a doctor. I can tell you are bias already should not make YouTube videos young lady for you get your facts in order

    1. @Chrono Trigger and what percentage of those low carb group were eating clean?

    2. They arent studied. They are told to follow are certain diet. They agree. And then they report back every 5 to 10 years and say ya ya Im still on the diet. Meanwhile most of them are lying and eating w.e they want.

  45. So do Inuits (strictly keto most of their lives) die earlier than any other populations that feed on plants? If they dont then this study is debunked whithout even having to look for funds to make a study 😉

  46. Even if only the one health benefit is that they lose weight then that is a good thing.

  47. The keto diet is a high fat/low carb diet not high protein as you stated in the video. The protein is only 20% or so in a meal with 5-10% in carbs from mainly greens and the fats are 70-75% coming from healthy saturated and unsaturated fats. So its not really high protein at all if you balance those ratios out accordingly!

  48. Is there a source to read the actual study? There are many factors to take into consideration, as to exactly why the individuals died. There have been many good studies done vs the single one, with conflicting results. Statistical data is not as reliable as looking at all the individual factors of those who died. A study in a medical journal is not the best reference. The medical world, in general, still holds onto the old study, that gave us the original food pyramid. We now know the sugar industry financed that study. The medical field overall, does not focus on the root cause of an issue either. Medication to treat symptoms is the preferred treatment. Metformin gave me a severe allergic reaction. The true Ketogenic diet reversed my type 2 diabetes, without medication. It also took off my dangerous midsection fat and lowered my BP., a1c and triglycerides. The Keto studies were published in more prominent medical journals, than The Lancet Journal, despite the poor acceptance by the medical world. We also know, that high cholesterol is not dangerous. It is necessary for life. The inflammation caused by carbs and sugars result in dangerous plaque forming in the circulatory system and brain. The cholesterol level in the blood is not the root cause. Studies that looked at groups who had low carb consumption and high fat consumption, along with plenty of exercise had much lower incidences of heart disease, dementia and Alzheimers. These groups were remote tribes and rural people who didnt have access to refined sugar, processed food and high carb food. Those few who developed the aforementioned diseases, despite the diet, were found to have genetic risk factors, Neither diet nor medication, would have eliminated the risks. If I could read the actual study and compare it to the many positive result Keto studies, I could make a determination, as to whether it was better done and thus dismiss previous studies.

  49. This is a plural version of a Poem I wrote originally with the word (she)

    I have this adjusted version to be applivable and Dedicated to the many, First Responders, physicians, nurses, medical staff, public safety, medivac, essential workers,, and all others who have selflessly devoted their time, labor, finances to aid in the Heath, and he process of our country and our world.

    They are Resilient, and Despite the sadness, 

    They Believe….

    They will Overcome any Depression, that stands in their way….

    They will keep Fighting, and will Not be defeated…

    They will NOT give up…
    They will find their inner Strength because…
    Gods Glow is with them…

    They Glow with the Love, Kindness…they carry for others…

    Advocate for Humanity,
    Author, Jason Sandifer,

  50. I think youre right its called moderation that word makes sense with everything almost

  51. As a new doctor you are naive about adopting practice options based on one paper. This data is based on questionnaire I would bet that most people reporting was inaccurate. How did they select their group and controls. Most nutrition studies are filled with bias. I have practice 40 year. I have done research and also have degrees in public health and PHD on top of my M. D. Please do not apply population studies to individual patients. I would advise you not to advise people outside your real expertise. You going on keto yourself shows your lack of knowledge on keto.
    Keto is a spectrum. It benefits some children with recalcitrant seizure. There is dirty keto and clean keto. Please Obese people and those with diabetes will benefit from restricted carbs and correction of their insulin resistance. This is not Atkins eat all and any kind of meat you want. Once you are at correct weight then you can modulate with keto cycling as you engage in more activities.
    As a physician I will never eat the fake soy meat and fake cheese and dairy and any GMO crap. I eat grass fed meat and dairy that is limited and my protein intake is based for my age and body size. I will eat whole plants mostly keto with rice potatoes and other high carb on days with most exercise. I also eat wild not farm raised lower mercury fish. Those mono crops that veggie promote are ruining our soil. You need to read more books and look at the data and research.

  52. 40% carbs is NOT KETO & dont get me started on surveys. Also carbs from plants effect your body differently than processed carbs. Also grass fed beef or grain fed beef? Correlation is not causation.

  53. I have had meat based keto for 4 years, lost weight came out of diabetes so dont know why you are saying this, I would question who did the analysis and by that I mean who actually paid for it…..veggie companies maybe?

  54. This is where I started and highly recommended its a 8 week meal plan they offer weekly grocery lists with recipes all put together based on your personal weight goal and food preferences but its more of a step by step walk through basically  its helped me out look into them!!!

  55. They might cover correlation Vs causation in your third year. They wont, but they might. And they should.

  56. But did the diet take into account how much and what type if exercise was performed? Lifesyle? What if keto people are naturally more reckless day to day and are drawn to the keto deit more. But it was their reckless ways that caused them to be unhealthy in other areas of life. The type of person draw n to a high bacon and steak diet may just be more reckless and enjoy extremes. Which may have made them be unhealthy in other areas of their lives.

  57. Put your violin playing on youtube if you want to be heard (please).

  58. They say you are what you eat. I’ll eat meat to be a little piggy then to be a vegetable after 80.

  59. It seems like you would want to review more than 1 study to make an educated decision. Its like taking the study that says sugar is good for you (sponsored and paid for by Coca-Cola) and basing your decision on that one study. I appreciate you sharing but please compare the results from multiple studies.

  60. No, the keto diet does not kill. It saves lives, like mine! If you doubt that the keto diet works, check out my transformation by searching YT using the phrase Low Carb Keto Diet Saved My Life rixcandoit and you can see before and after pictures of what happened to me in 12 weeks. It literally saved my life. Seriously, you all can do this.

  61. All the keto people on here getting real upset that their fad diet isnt the healthiest thing in the world lol.

    In the end it isnt hard to figure out what is healthy. Mainly plant based diet with healthy fats and proteins and moderate your sugar intake.

  62. What is the best way to lost a ton of fat? I read lots of good reviews on the internet about how exactly Custokebon Secrets can help you lost a lot of fat. Has anybody tested out this popular lose weight diet plan?

  63. Screaming for attention on social media like YouTube through recording pointless videos like that kills.

  64. What about the people in the 70% + carb group, did they make a ifference between white sugar / floor consumption and sweet potatoes and fruits?

  65. I believe the flaw in your reasoning comes from the study itself due to funding by the NIH, which is filled with corruption and fraud. It silences whistleblowers while effectively working for big Pharma and the medical-industrial establishment.

  66. Thanks for sharing. I think the Paleo people will not appreciate this video since you are speaking against their diet. I agree with you, and I try to eat healthy carbs in moderation.

  67. Hello Doctor, can you discuss the best meal plan which is simple and affordable and healthy for everyday consumption- thanks Im a Filipino:)

  68. You have a bias. Youve decided what to believe, considered that one ridiculous research that supports what you want to believe and ignored actual research that shows the benefits of keto but doesnt support what you want to believe, which is plant based diets are better. Irresponsible and misleading video.

  69. You are shocking! You’re only a year two and yet believe you are qualified enough to lecture on this and give out BIG sensational and incorrect headline! I’ve just read the entire Lancet paper and your understanding and claims are rubbish. There are SO many unknown influences and factors that it even acknowledges the results are based solely on suppositions and answers to high level questionnaires. When the study was started no one had even known of the term keto.
    You should NOT take statements out of context.
    I pity your patients if that’s how you review their illnesses.

  70. So when are they going to do a 30 year study of actual keto? 40% inflammatory carbs isn’t Keto.

  71. What if we have veggie keto or meat keto for around 2 months , then turn slowly backwards to normal diet with controlled carbs.

  72. Im on a keto diet and i stopped craving sugar as now i find it repulsive

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